The Holy Monastery of Agios Nikolaos is a Greek Orthodox Monastery in Metsovo, in the region of Epirus in Northern Greece. It is the oldest monastery in the area, its founding dating back to the 14th century. Its was partly destroyed in 1453 and rebuilt in 1700. By 1925 it had fallen into abandonment, and its historic painted decoration had suffered significant damage. In 1960 and 1984, extensive restoration works were undertaken, financed by the Averof–Tositsas Foundation. Since 2017 it has been repopulated by monks.